Molecular diagnosis of scabies using a novel probe-based polymerase chain reaction assay targeting high-copy number repetitive sequences in the Sarcoptes scabiei genome.

• Main Authors: Lena Chng (Author), Deborah C Holt (Author), Matt Field (Author), Joshua R Francis (Author), Dev Tilakaratne (Author), Milou H Dekkers (Author), Greg Robinson (Author), Kate Mounsey (Author), Rebecca Pavlos (Author), Asha C Bowen (Author), Katja Fischer (Author), Anthony T Papenfuss (Author), Robin B Gasser (Author), Pasi K Korhonen (Author), Bart J Currie (Author), James S McCarthy (Author), Cielo Pasay (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

<h4>Background</h4>The suboptimal sensitivity and specificity of available diagnostic methods for scabies hampers clinical management, trials of new therapies and epidemiologic studies. Additionally, parasitologic diagnosis by microscopic examination of skin scrapings requires sample col...