Understanding inter-individual variability in pharmacokinetics/pharmacodynamics of aripiprazole in children with tic disorders: Individualized administration based on physiological development and CYP2D6 genotypes

• Main Authors: Yingying Xin (Author), Liuliu Gao (Author), Yali Tuo (Author), Gang Nie (Author), Yan Mei (Author), Chen Chen (Author), Jun Wang (Author), Sichan Li (Author), Dan Sun (Author), Qiaoqiao Qian (Author), Yongli Fu (Author), Yang Wang (Author), Zhisheng Liu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: This study aims to develop a combined population pharmacokinetic (PPK) model for aripiprazole (ARI) and its main active metabolite dehydroaripiprazole (DARI) in pediatric patients with tic disorders (TD), to investigate the inter-individual variability caused by physiological and genetic...