Phosphodiesterase 4 inhibitors attenuate virus‐induced activation of eosinophils from asthmatics without affecting virus binding

• Main Authors: Yanaika Shari Sabogal Piñeros (Author), Tamara Dekker (Author), Barbara Smids (Author), Christof J. Majoor (Author), Lara Ravanetti (Author), Gino Villetti (Author), Maurizio Civelli (Author), Fabrizio Facchinetti (Author), René Lutter (Author)
• Format: Book
• Published: Wiley, 2020-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Acute respiratory virus infections, such as influenza and RSV, are predominant causes of asthma exacerbations. Eosinophils act as a double‐edged sword in exacerbations in that they are activated by viral infections but also can capture and inactivate respiratory viruses. Phosphodiesterase t...