Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice

• Hlavní autoři: Parameswaran Gangadharan Sreekumar (Autor), Feng Su (Autor), Christine Spee (Autor), Elise Hong (Autor), Ravikiran Komirisetty (Autor), Eduardo Araujo (Autor), Steven Nusinowitz (Autor), Srinivasa T. Reddy (Autor), Ram Kannan (Autor)
• Médium: Kniha
• Vydáno: MDPI AG, 2023-09-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein that is found intracellularly associated with mitocho...