Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice

• Main Authors: Parameswaran Gangadharan Sreekumar (Author), Feng Su (Author), Christine Spee (Author), Elise Hong (Author), Ravikiran Komirisetty (Author), Eduardo Araujo (Author), Steven Nusinowitz (Author), Srinivasa T. Reddy (Author), Ram Kannan (Author)
• Format: Book
• Published: MDPI AG, 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Although AMD is a complex disease, oxidative stress is a crucial contributor to its development, especially in view of the higher oxygen demand of the retina. Paraoxonase 2 (PON2) is a ubiquitously and constitutively expressed antioxidant protein that is found intracellularly associated with mitocho...