Formulation and Characterization of Eplerenone Nanoemulsion Liquisolids, An Oral Delivery System with Higher Release Rate and Improved Bioavailability

• Autore principale: Ahmed Khames (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2019-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Because Eplerenone (EPL) is a Biopharmaceutical Classification System (BCS) class-II drug and is prone to extensive liver degradation, it suffers from poor bioavailability after oral administration. This work aimed to prepare liquisolids loaded with EPL-nanoemulsions (EPL-NEs) that have a higher dru...