Novel Anti-Interleukin-1β Therapy Preserves Retinal Integrity: A Longitudinal Investigation Using OCT Imaging and Automated Retinal Segmentation in Small Rodents

• Main Authors: Diane N. Sayah (Author), Tianwei E. Zhou (Author), Samy Omri (Author), Javier Mazzaferri (Author), Christiane Quiniou (Author), Maëlle Wirth (Author), France Côté (Author), Rabah Dabouz (Author), Michel Desjarlais (Author), Santiago Costantino (Author), Sylvain Chemtob (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Retinopathy of prematurity (ROP) is the leading cause of blindness in neonates. Inflammation, in particular interleukin-1β (IL-1β), is increased in early stages of the disorder, and contributes to inner and outer retinal vasoobliteration in the oxygen-induced retinopathy (OIR) model of ROP. A small...