Effects of the HIV‐1 maturation inhibitor GSK3640254 on QT interval in healthy participants

• Main Authors: Ying Zhang (Author), Mark Bush (Author), Parto Yazdani (Author), Joyce Zhan (Author), Bo Wen (Author), Veronica Bainbridge (Author), Brian R. Wynne (Author), Samit Joshi (Author), Max Lataillade (Author)
• Format: Book
• Published: Wiley, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract GSK3640254 (GSK'254) is a novel HIV‐1 maturation inhibitor with pharmacokinetics supporting once‐daily (QD) therapy for HIV‐1 treatment. This thorough QT/corrected QT (QTc) study evaluated the effect of GSK'254 on cardiac repolarization. In this two‐part, randomized study, healthy...