Effect of Egg White Combined with Chalcanthite on Lipopolysaccharide induced Inflammatory Cytokine Expression in RAW 264.7 cells
Historically, mineral compound herbal medicines have long been used in treatments of immune-related diseases in Korea, China and other Asian countries. In this study, we inv-estigated the anti-inflammatory effect of egg white combined with chalcanthite (IS4) on lipopolysaccharide (LPS)-stimulated RA...
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| Main Authors: | , , , , |
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| Format: | Book |
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Korean Pharmacopuncture Institute,
2012-03-01T00:00:00Z.
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| Summary: | Historically, mineral compound herbal medicines have long been used in treatments of immune-related diseases in Korea, China and other Asian countries. In this study, we inv-estigated the anti-inflammatory effect of egg white combined with chalcanthite (IS4) on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells. RAW 264.7 cells cultured with LPS and various con-centrations of IS4 were analyzed to determine the production of pro-inflammatory cytokines and mediators by using enzyme-linked immune sorbent assays (ELISAs). IS4 concentration inhibited the production of interleukin-1beta (IL-1β), interleukin-6 (IL-6), and granulocyte-macrophage colony-stimulating factor (GM-CSF) induced by LPS. IS4 at high concentrations (25 and 50`㎍/ml) inhibited, in concentration-dependent manner, the expression of tumor necrosis factor-alpha (TNF-α) stimulated by LPS. IS4 has shown an anti-inflammatory effect in RAW 264.7 cells. |
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| Item Description: | 10.3831/KPI.2012.15.1.007 2093-6966 2234-6856 |