Strong interferon-gamma mediated cellular immunity to scrub typhus demonstrated using a novel whole cell antigen ELISpot assay in rhesus macaques and humans.

• Main Authors: Manutsanun Sumonwiriya (Author), Daniel H Paris (Author), Piyanate Sunyakumthorn (Author), Tippawan Anantatat (Author), Kemajittra Jenjaroen (Author), Suchintana Chumseng (Author), Rawiwan Im-Erbsin (Author), Ampai Tanganuchitcharnchai (Author), Suthatip Jintaworn (Author), Stuart D Blacksell (Author), Fazle R Chowdhury (Author), Barbara Kronsteiner (Author), Prapit Teparrukkul (Author), Robin L Burke (Author), Eric D Lombardini (Author), Allen L Richards (Author), Carl J Mason (Author), James W Jones (Author), Nicholas P J Day (Author), Susanna J Dunachie (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Scrub typhus is a febrile infection caused by the obligate intracellular bacterium Orientia tsutsugamushi, which causes significant morbidity and mortality across the Asia-Pacific region. The control of this vector-borne disease is challenging due to humans being dead-end hosts, vertical maintenance...