Tyrosine and aurora kinase inhibitors diminish transport function of multidrug resistance-associated protein (MRP) 4 and breast cancer resistance protein (BCRP)

• Main Authors: Rhiannon N. Hardwick (Author), Marina Snellings (Author), Brian C. Ferslew (Author), Yang Lu (Author), Kim L.R. Browuer (Author)
• Format: Book
• Published: International Association of Physical Chemists (IAPC), 2016-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Tyrosine and aurora kinases are important effectors in signal transduction pathways that are often involved in aberrant cancer cell growth. Tyrosine (TKI) and aurora (AKI) kinase inhibitors are anti-cancer agents specifically designed to target such signaling pathways through TKI/AKI binding to the...