GPR142 prompts glucagon-like Peptide-1 release from islets to improve β cell function

• Main Authors: Hua V. Lin (Author), Jingru Wang (Author), Jie Wang (Author), Weiji Li (Author), Xuesong Wang (Author), James T. Alston (Author), Melissa K. Thomas (Author), Daniel A. Briere (Author), Samreen K. Syed (Author), Alexander M. Efanov (Author)
• Format: Book
• Published: Elsevier, 2018-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: GPR142 agonists are being pursued as novel diabetes therapies by virtue of their insulin secretagogue effects. But it is undetermined whether GPR142's functions in pancreatic islets are limited to regulating insulin secretion. The current study expands research on its action. Methods...