Long-Term PEDF Release in Rat Iris and Retinal Epithelial Cells after Sleeping Beauty Transposon-Mediated Gene Delivery

• Main Authors: Laura Garcia-Garcia (Author), Sergio Recalde (Author), Maria Hernandez (Author), Jaione Bezunartea (Author), Juan Roberto Rodriguez-Madoz (Author), Sandra Johnen (Author), Sabine Diarra (Author), Corinne Marie (Author), Zsuzsanna Izsvák (Author), Zoltán Ivics (Author), Daniel Scherman (Author), Martina Kropp (Author), Gabriele Thumann (Author), Felipe Prosper (Author), Patricia Fernandez-Robredo (Author), Alfredo Garcia-Layana (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Pigment epithelium derived factor (PEDF) is a potent antiangiogenic, neurotrophic, and neuroprotective molecule that is the endogenous inhibitor of vascular endothelial growth factor (VEGF) in the retina. An ex vivo gene therapy approach based on transgenic overexpression of PEDF in the eye is assum...