Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery

• Main Authors: Cheng Qian (Author), Yueke Zhou (Author), Teng Zhang (Author), Guanglu Dong (Author), Mengyao Song (Author), Yu Tang (Author), Zhonghong Wei (Author), Suyun Yu (Author), Qiuhong Shen (Author), Wenxing Chen (Author), Jaesung P. Choi (Author), Juming Yan (Author), Chongjin Zhong (Author), Li Wan (Author), Jia Li (Author), Aiyun Wang (Author), Yin Lu (Author), Yang Zhao (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors, and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor progression. Herein, we demonstrated that salvianic acid A (SAA) pla...