Drp1 acetylation mediated by CDK5-AMPK-GCN5L1 axis promotes cerebral ischemic injury via facilitating mitochondrial fission

• Main Authors: Jiejie Zhang (Author), Shan Wang (Author), Haitao Zhang (Author), Xiaotong Yang (Author), Xin Ren (Author), Lei Wang (Author), Yihan Yang (Author), Yi Yang (Author), Ya Wen (Author)
• Format: Book
• Published: BMC, 2024-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract The aberrant acetylation of mitochondrial proteins is involved in the pathogenesis of multiple diseases including neurodegenerative diseases and cerebral ischemic injury. Previous studies have shown that depletion of mitochondrial NAD+, which is necessary for mitochondrial deacetylase activ...