A static-cidal assay for Trypanosoma brucei to aid hit prioritisation for progression into drug discovery programmes.

• Main Authors: Manu De Rycker (Author), Sandra O'Neill (Author), Dhananjay Joshi (Author), Lorna Campbell (Author), David W Gray (Author), Alan H Fairlamb (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human African Trypanosomiasis is a vector-borne disease of sub-Saharan Africa that causes significant morbidity and mortality. Current therapies have many drawbacks, and there is an urgent need for new, better medicines. Ideally such new treatments should be fast-acting cidal agents that cure the di...