Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

• 主要な著者: Zhen Liu (著者), Ye Xu (著者), Lvqian Guo (著者), Xinran Li (著者), Junling Gao (著者), Weiran Xie (著者), Lianbo Zhao (著者), Yuou Teng (著者), Xuejiao Li (著者), Peng Yu (著者)
• フォーマット: 図書
• 出版事項: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

The effect of the combination of 10-Hydroxycamptothecin (HCPT) and crizotinib (CRI) on EGFR- and KRAS-mutant lung cancer cells was investigated and the conjugates of the two drugs were synthesised. HCPT combined with CRI synergistically inhibited the cell growth and proliferation of H1975, HCC827, a...