Development of 10-Hydroxycamptothecin-crizotinib conjugate based on the synergistic effect on lung cancer cells

• Main Authors: Zhen Liu (Author), Ye Xu (Author), Lvqian Guo (Author), Xinran Li (Author), Junling Gao (Author), Weiran Xie (Author), Lianbo Zhao (Author), Yuou Teng (Author), Xuejiao Li (Author), Peng Yu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2023-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of the combination of 10-Hydroxycamptothecin (HCPT) and crizotinib (CRI) on EGFR- and KRAS-mutant lung cancer cells was investigated and the conjugates of the two drugs were synthesised. HCPT combined with CRI synergistically inhibited the cell growth and proliferation of H1975, HCC827, a...