Oxidative Stress-Induced Misfolding and Inclusion Formation of Nrf2 and Keap1

• Main Authors: Vy Ngo (Author), Nadun C. Karunatilleke (Author), Anne Brickenden (Author), Wing-Yiu Choy (Author), Martin L. Duennwald (Author)
• Formato: Livro
• Publicado em: MDPI AG, 2022-01-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

Cells that experience high levels of oxidative stress respond by inducing antioxidant proteins through activation of the protein transcription factor nuclear factor erythroid 2-related factor 2 (Nrf2). Nrf2 is negatively regulated by the E3 ubiquitin ligase Kelch-like ECH-associated protein 1 (Keap1...