Synthesis and Biological Evaluation of <i>O</i>⁶-Aminoalkyl-Hispidol Analogs as Multifunctional Monoamine Oxidase-B Inhibitors towards Management of Neurodegenerative Diseases

• Main Authors: Ahmed H. E. Hassan (Author), Hyeon Jeong Kim (Author), Keontae Park (Author), Yeonwoo Choi (Author), Suyeon Moon (Author), Chae Hyeon Lee (Author), Yeon Ju Kim (Author), Soo Bin Cho (Author), Min Sung Gee (Author), Danbi Lee (Author), Jong-Hyun Park (Author), Jong Kil Lee (Author), Jong Hoon Ryu (Author), Ki Duk Park (Author), Yong Sup Lee (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative catabolism of monoamine neurotransmitters by monoamine oxidases (MAOs) produces reactive oxygen species (ROS), which contributes to neuronal cells' death and also lowers monoamine neurotransmitter levels. In addition, acetylcholinesterase activity and neuroinflammation are involved in...