MicroRNA-208a Dysregulates Apoptosis Genes Expression and Promotes Cardiomyocyte Apoptosis during Ischemia and Its Silencing Improves Cardiac Function after Myocardial Infarction

• Автори: Hasahya Tony (Автор), Kai Meng (Автор), Bangwei Wu (Автор), Aijia Yu (Автор), Qiutang Zeng (Автор), Kunwu Yu (Автор), Yucheng Zhong (Автор)
• Формат: Книга
• Опубліковано: Hindawi Limited, 2015-01-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Aims. miR-208a is associated with adverse outcomes in several cardiac pathologies known to have increased apoptosis, including myocardial infarction (MI). We investigated if miR-208a has proapoptotic effects on ischemic cardiomyocytes and if its silencing has therapeutic benefits in MI. Methods and...