Genetic and cellular sensitivity of Caenorhabditis elegans to the chemotherapeutic agent cisplatin

• Main Authors: Francisco Javier García-Rodríguez (Author), Carmen Martínez-Fernández (Author), David Brena (Author), Dmytro Kukhtar (Author), Xènia Serrat (Author), Ernest Nadal (Author), Mike Boxem (Author), Sebastian Honnen (Author), Antonio Miranda-Vizuete (Author), Alberto Villanueva (Author), Julián Cerón (Author)
• Format: Book
• Published: The Company of Biologists, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cisplatin and derivatives are commonly used as chemotherapeutic agents. Although the cytotoxic action of cisplatin on cancer cells is very efficient, clinical oncologists need to deal with two major difficulties, namely the onset of resistance to the drug and the cytotoxic effect in patients. Here,...