An Albumin-Oligonucleotide Assembly for Potential Combinatorial Drug Delivery and Half-Life Extension Applications

• Main Authors: Matthias Kuhlmann (Author), Jonas B.R. Hamming (Author), Anders Voldum (Author), Georgia Tsakiridou (Author), Maja T. Larsen (Author), Julie S. Schmøkel (Author), Emil Sohn (Author), Konrad Bienk (Author), David Schaffert (Author), Esben S. Sørensen (Author), Jesper Wengel (Author), Daniel M. Dupont (Author), Kenneth A. Howard (Author)
• Format: Book
• Published: Elsevier, 2017-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The long blood circulatory property of human serum albumin, due to engagement with the cellular recycling neonatal Fc receptor (FcRn), is an attractive drug half-life extension enabling technology. This work describes a novel site-specific albumin double-stranded (ds) DNA assembly approach, in which...