Discovery of indole-3-butyric acid derivatives as potent histone deacetylase inhibitors

• Κύριοι συγγραφείς: Yiming Chen (Συγγραφέας), Lihui Zhang (Συγγραφέας), Lin Zhang (Συγγραφέας), Qixiao Jiang (Συγγραφέας), Lei Zhang (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

In discovery of HDAC inhibitors (HDACIs) with improved anticancer potency, structural modification was performed on the previous derived indole-3-butyric acid derivative. Among all the synthesised compounds, molecule I13 exhibited high HDAC inhibitory and antiproliferative potencies in the in vitro...