Astrocyte EV-Induced lincRNA-Cox2 Regulates Microglial Phagocytosis: Implications for Morphine-Mediated Neurodegeneration

• Main Authors: Guoku Hu (Author), Ke Liao (Author), Fang Niu (Author), Lu Yang (Author), Blake W. Dallon (Author), Shannon Callen (Author), Changhai Tian (Author), Jiang Shu (Author), Juan Cui (Author), Zhiqiang Sun (Author), Yuri L. Lyubchenko (Author), Minhan Ka (Author), Xian-Ming Chen (Author), Shilpa Buch (Author)
• Format: Book
• Published: Elsevier, 2018-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Impairment of microglial functions, such as phagocytosis and/or dysregulation of immune responses, has been implicated as an underlying factor involved in the pathogenesis of various neurodegenerative disorders. Our previous studies have demonstrated that long intergenic noncoding RNA (lincRNA)-Cox2...