JAK inhibition ameliorates bone destruction by simultaneously targeting mature osteoclasts and their precursors

• Main Authors: Shinya Yari (Author), Junichi Kikuta (Author), Hotaka Shigyo (Author), Yu Miyamoto (Author), Daisuke Okuzaki (Author), Yuki Furusawa (Author), Masafumi Minoshima (Author), Kazuya Kikuchi (Author), Masaru Ishii (Author)
• Format: Knjiga
• Izdano: BMC, 2023-03-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

Abstract Background Rheumatoid arthritis (RA) is characterized by chronic inflammation and resultant cartilage/bone destruction because of aberrantly activated osteoclasts. Recently, novel treatments with several Janus kinase (JAK) inhibitors have been shown to successfully ameliorate arthritis-rela...