Development of a Library of Disulfide Bond-Containing Cationic Lipids for mRNA Delivery

• Main Authors: Zhigao Shen (Author), Cong Liu (Author), Ziqian Wang (Author), Fengfei Xie (Author), Xingwu Liu (Author), Lingkai Dong (Author), Xuehua Pan (Author), Chen Zeng (Author), Peng George Wang (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Lipid nanoparticles (LNPs) are the commonly used delivery tools for messenger RNA (mRNA) therapy and play an indispensable role in the success of COVID-19 mRNA vaccines. Ionizable cationic lipids are the most important component in LNPs. Herein, we developed a series of new ionizable lipids featurin...