Fenofibrate Decreases Ethanol-Induced Neuroinflammation and Oxidative Stress and Reduces Alcohol Relapse in Rats by a PPAR-α-Dependent Mechanism

• मुख्य लेखकों: Cristina Ibáñez (लेखक), Tirso Acuña (लेखक), María Elena Quintanilla (लेखक), Diliana Pérez-Reytor (लेखक), Paola Morales (लेखक), Eduardo Karahanian (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2023-09-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

High ethanol consumption triggers neuroinflammation, implicated in sustaining chronic alcohol use. This inflammation boosts glutamate, prompting dopamine release in reward centers, driving prolonged drinking and relapse. Fibrate drugs, activating peroxisome proliferator-activated receptor alpha (PPA...