Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Accumulation of 3-hydroxytetradecenoic acid: Cause or corollary of glucolipotoxic impairment of pancreatic β-cell bioenergetics?

Objectives: Hyperglycemia and elevated blood lipids are the presumed precipitating causes of β-cell damage in T2DM as the result of a process termed "glucolipotoxicity". Here, we tested whether glucolipotoxic pathophysiology is caused by defective bioenergetics using islets in culture. Met...

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Main Authors: Nicolai M. Doliba (Author), Qing Liu (Author), Changhong Li (Author), Jie Chen (Author), Pan Chen (Author), Chengyang Liu (Author), David W. Frederick (Author), Joseph A. Baur (Author), Michael J. Bennett (Author), Ali Naji (Author), Franz M. Matschinsky (Author)
Format: Book
Published: Elsevier, 2015-12-01T00:00:00Z.
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