Pyridoxamine Limits Cardiac Dysfunction in a Rat Model of Doxorubicin-Induced Cardiotoxicity

• Main Authors: Sibren Haesen (Author), Manon Marie Jager (Author), Aline Brillouet (Author), Iris de Laat (Author), Lotte Vastmans (Author), Eline Verghote (Author), Anouk Delaet (Author), Sarah D'Haese (Author), Ibrahim Hamad (Author), Markus Kleinewietfeld (Author), Jeroen Mebis (Author), Wilfried Mullens (Author), Ivo Lambrichts (Author), Esther Wolfs (Author), Dorien Deluyker (Author), Virginie Bito (Author)
• Format: Book
• Published: MDPI AG, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The use of doxorubicin (DOX) chemotherapy is restricted due to dose-dependent cardiotoxicity. Pyridoxamine (PM) is a vitamin B6 derivative with favorable effects on diverse cardiovascular diseases, suggesting a cardioprotective effect on DOX-induced cardiotoxicity. The cardioprotective nature of PM...