Elevated RIF1 participates in the epigenetic abnormalities of zygotes by regulating histone modifications on MuERV-L in obese mice

• المؤلفون الرئيسيون: Jiliang Huang (مؤلف), Gaizhen Ru (مؤلف), Jiajia Sun (مؤلف), Luying Sun (مؤلف), Zhiling Li (مؤلف)
• التنسيق: كتاب
• منشور في: BMC, 2022-02-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Abstract Background Maternal obesity impairs embryonic developmental potential and significantly increases the risks of metabolic disorders in offspring. However, the epigenetic transmission mechanism of maternal metabolic abnormalities is still poorly understood. Methods We established an obesity m...