Caspase Cascade Proceeds Rapidly After Cytochrome c Release From Mitochondria in Tumor Necrosis Factor-α-Induced Cell Death

• Main Authors: Hiroshi Kawai (Author), Takuo Suzuki (Author), Tetsu Kobayashi (Author), Akiko Ishii-Watabe (Author), Haruna Sakurai (Author), Hisayuki Ohata (Author), Kazuo Honda (Author), Kazutaka Momose (Author), Takao Hayakawa (Author), Toru Kawanishi (Author)
• Format: Book
• Published: Elsevier, 2007-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The caspase activation cascade and mitochondrial changes are major biochemical reactions in the apoptotic cell death machinery. We attempted to clarify the temporal relationship between caspase activation, cytochrome c release, mitochondrial depolarization, and morphological changes that take place...