Quercetin and Isorhamnetin Attenuate Benzo[a]pyrene-Induced Toxicity by Modulating Detoxification Enzymes through the AhR and NRF2 Signaling Pathways

• Egile Nagusiak: Min Kim (Egilea), Seung-Cheol Jee (Egilea), Kyeong-Seok Kim (Egilea), Hyung-Sik Kim (Egilea), Kyoung-Nae Yu (Egilea), Jung-Suk Sung (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2021-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Benzo[a]pyrene, classified as a Group 1 carcinogen, is metabolized to B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE), causing DNA mutations and eventually cancer. Quercetin is a dietary flavonoid abundant in fruits and vegetables. After quercetin intake, quercetin's metabolites isorhamnetin and miqu...