An mRNA-Based Multiple Antigenic Gene Expression System Delivered by Engineered <i>Salmonella</i> for Severe Fever with Thrombocytopenia Syndrome and Assessment of Its Immunogenicity and Protection Using a Human DC-SIGN-Transduced Mouse Model

• Main Authors: Ji-Young Park (Author), Chamith Hewawaduge (Author), Chandran Sivasankar (Author), Khristine Kaith S. Lloren (Author), Byungkwan Oh (Author), Mi Young So (Author), John Hwa Lee (Author)
• Format: Book
• Published: MDPI AG, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Currently, there are no commercial vaccines or therapeutics against severe fever with thrombocytopenia syndrome (SFTS) virus. This study explored an engineered Salmonella as a vaccine carrier to deliver a eukaryotic self-mRNA replicating vector, pJHL204. This vector expresses multiple SFTS virus ant...