A Novel Chalcone Polyphenol Inhibits the Deacetylase Activity of SIRT1 and Cell Growth in HEK293T Cells

• Main Authors: Tomoaki Kahyo (Author), Shuji Ichikawa (Author), Takahiro Hatanaka (Author), Maki K. Yamada (Author), Mitsutoshi Setou (Author)
• Format: Knjiga
• Izdano: Elsevier, 2008-01-01T00:00:00Z.
• Teme: article
• Online dostop: Connect to this object online.

SIRT1 is one of seven mammalian orthologs of yeast silent information regulator 2 (Sir2), and it functions as a nicotinamide adenine dinucleotide (NAD)-dependent deacetylase. Recently, resveratrol and its analogues, which are polyphenols, have been reported to activate the deacetylase activity of SI...