Population pharmacokinetics and limited sampling strategy for therapeutic drug monitoring of mycophenolate mofetil in Japanese patients with lupus nephritis

• Main Authors: Tomoko Mizaki (Author), Hironobu Nobata (Author), Shogo Banno (Author), Makoto Yamaguchi (Author), Hiroshi Kinashi (Author), Shiho Iwagaitsu (Author), Takuji Ishimoto (Author), Yukiko Kuru (Author), Masafumi Ohnishi (Author), Ken-ichi Sako (Author), Yasuhiko Ito (Author)
• Format: Book
• Published: BMC, 2023-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Mycophenolate mofetil (MMF), a prodrug of the immunosuppressive agent mycophenolic acid (MPA), is difficult to administer because of the pharmacokinetic complexity of MPA. Although dosage adjustment according to the 12-h area under the concentration-time curve (AUC0-12) is though...