Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis

• Hauptverfasser: Camille Lefevre (Verfasst von), Morgane M. Thibaut (Verfasst von), Audrey Loumaye (Verfasst von), Jean-Paul Thissen (Verfasst von), Audrey M. Neyrinck (Verfasst von), Benoit Navez (Verfasst von), Nathalie M. Delzenne (Verfasst von), Olivier Feron (Verfasst von), Laure B. Bindels (Verfasst von)
• Format: Buch
• Veröffentlicht: Elsevier, 2024-05-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

Objective: Tumour progression drives profound alterations in host metabolism, such as adipose tissue depletion, an early event of cancer cachexia. As fatty acid consumption by cancer cells increases upon acidosis of the tumour microenvironment, we reasoned that fatty acids derived from distant adipo...