Tumoral acidosis promotes adipose tissue depletion by fostering adipocyte lipolysis

• Main Authors: Camille Lefevre (Author), Morgane M. Thibaut (Author), Audrey Loumaye (Author), Jean-Paul Thissen (Author), Audrey M. Neyrinck (Author), Benoit Navez (Author), Nathalie M. Delzenne (Author), Olivier Feron (Author), Laure B. Bindels (Author)
• Format: Book
• Published: Elsevier, 2024-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Tumour progression drives profound alterations in host metabolism, such as adipose tissue depletion, an early event of cancer cachexia. As fatty acid consumption by cancer cells increases upon acidosis of the tumour microenvironment, we reasoned that fatty acids derived from distant adipo...