3D cell culture models: Drug pharmacokinetics, safety assessment, and regulatory consideration

• Main Authors: Hongbing Wang (Author), Paul C. Brown (Author), Edwin C.Y. Chow (Author), Lorna Ewart (Author), Stephen S. Ferguson (Author), Suzanne Fitzpatrick (Author), Benjamin S. Freedman (Author), Grace L. Guo (Author), William Hedrich (Author), Scott Heyward (Author), James Hickman (Author), Nina Isoherranen (Author), Albert P. Li (Author), Qi Liu (Author), Shannon M. Mumenthaler (Author), James Polli (Author), William R. Proctor (Author), Alexandre Ribeiro (Author), Jian‐Ying Wang (Author), Ronald L. Wange (Author), Shiew‐Mei Huang (Author)
• Format: Book
• Published: Wiley, 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Nonclinical testing has served as a foundation for evaluating potential risks and effectiveness of investigational new drugs in humans. However, the current two‐dimensional (2D) in vitro cell culture systems cannot accurately depict and simulate the rich environment and complex processes ob...