Alternative Pharmacokinetic Metrics in Single-Dose Studies to Ensure Bioequivalence of Prolonged-Release Products at Steady State-A Case Study

• Egile Nagusiak: Víctor Mangas-Sanjuán (Egilea), Marta Simón (Egilea), Esperanza González-Rojano (Egilea), Dolores Ochoa (Egilea), Francisco Abad-Santos (Egilea), Manuel Román (Egilea), Mercedes Ramos (Egilea), Carlos Govantes (Egilea), Alfredo García-Arieta (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2023-01-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

(1) Background: this article investigates which PK metrics in a single-dose study (concentration at the end of posology interval, C_τ, partial areas under the curve, pAUCs, or half-value duration, HVD) are more sensitive and less variable for predicting the failure of a prolong...