Alternative Pharmacokinetic Metrics in Single-Dose Studies to Ensure Bioequivalence of Prolonged-Release Products at Steady State-A Case Study

• 主要な著者: Víctor Mangas-Sanjuán (著者), Marta Simón (著者), Esperanza González-Rojano (著者), Dolores Ochoa (著者), Francisco Abad-Santos (著者), Manuel Román (著者), Mercedes Ramos (著者), Carlos Govantes (著者), Alfredo García-Arieta (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2023-01-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

(1) Background: this article investigates which PK metrics in a single-dose study (concentration at the end of posology interval, C_τ, partial areas under the curve, pAUCs, or half-value duration, HVD) are more sensitive and less variable for predicting the failure of a prolong...