c-Abl Phosphorylates MFN2 to Regulate Mitochondrial Morphology in Cells under Endoplasmic Reticulum and Oxidative Stress, Impacting Cell Survival and Neurodegeneration

• Main Authors: Alexis Martinez (Author), Cristian M. Lamaizon (Author), Cristian Valls (Author), Fabien Llambi (Author), Nancy Leal (Author), Patrick Fitzgerald (Author), Cliff Guy (Author), Marcin M. Kamiński (Author), Nibaldo C. Inestrosa (Author), Brigitte van Zundert (Author), Gonzalo I. Cancino (Author), Andrés E. Dulcey (Author), Silvana Zanlungo (Author), Juan J. Marugan (Author), Claudio Hetz (Author), Douglas R. Green (Author), Alejandra R. Alvarez (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The endoplasmic reticulum is a subcellular organelle key in the control of synthesis, folding, and sorting of proteins. Under endoplasmic reticulum stress, an adaptative unfolded protein response is activated; however, if this activation is prolonged, cells can undergo cell death, in part due to oxi...