Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer's Disease

• Main Authors: Ena Španić Popovački (Author), Mirjana Babić Leko (Author), Lea Langer Horvat (Author), Klara Brgić (Author), Željka Vogrinc (Author), Marina Boban (Author), Nataša Klepac (Author), Fran Borovečki (Author), Goran Šimić (Author)
• Format: Book
• Published: MDPI AG, 2023-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Individuals with specific <i>TREM2</i> gene variants that encode for a Triggering Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease (AD). By interacting with amyloid and apolipoproteins, the TREM2 receptor regulates the number of myelo...