Soluble TREM2 Concentrations in the Cerebrospinal Fluid Correlate with the Severity of Neurofibrillary Degeneration, Cognitive Impairment, and Inflammasome Activation in Alzheimer's Disease

• প্রধান লেখক: Ena Španić Popovački (লেখক), Mirjana Babić Leko (লেখক), Lea Langer Horvat (লেখক), Klara Brgić (লেখক), Željka Vogrinc (লেখক), Marina Boban (লেখক), Nataša Klepac (লেখক), Fran Borovečki (লেখক), Goran Šimić (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2023-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Background: Individuals with specific <i>TREM2</i> gene variants that encode for a Triggering Receptor Expressed on Myeloid cells 2 have a higher prevalence of Alzheimer's disease (AD). By interacting with amyloid and apolipoproteins, the TREM2 receptor regulates the number of myelo...