Population Pharmacokinetics and Initial Dosage Optimization of Tacrolimus in Pediatric Hematopoietic Stem Cell Transplant Patients

• Main Authors: Xiao-Lin Liu (Author), Yan-Ping Guan (Author), Ying Wang (Author), Ke Huang (Author), Fu-Lin Jiang (Author), Jian Wang (Author), Qi-Hong Yu (Author), Kai-Feng Qiu (Author), Min Huang (Author), Jun-Yan Wu (Author), Dun-Hua Zhou (Author), Guo-Ping Zhong (Author), Xiao-Xia Yu (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: There is a substantial lack of tacrolimus pharmacokinetic information in pediatric hematopoietic stem cell transplant (HSCT) patients. This study aimed to develop population pharmacokinetics (PopPK) of tacrolimus in pediatric HSCT patients and to devise model-guided dosage regimens.Metho...