Preserving the Integrity of Liposomes Prepared by Ethanol Injection upon Freeze-Drying: Insights from Combined Molecular Dynamics Simulations and Experimental Data

Preserving the Integrity of Liposomes Prepared by Ethanol Injection upon Freeze-Drying: Insights from Combined Molecular Dynamics Simulations and Experimental Data

The freeze-drying of complex formulations, such as liposomes, is challenging, particularly if dispersions contain residual organic solvents. This work aimed to investigate the effects of possible protectants, namely sucrose, trehalose and/or poly(vinyl pyrrolidone) (PVP), on the main features of the...

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Main Authors: Silvia Franzè (Author), Francesca Selmin (Author), Paolo Rocco (Author), Giuseppe Colombo (Author), Antonella Casiraghi (Author), Francesco Cilurzo (Author)
Format: Book
Published: MDPI AG, 2020-06-01T00:00:00Z.
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