Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice

• Main Authors: Hyun-Jung Park (Author), Malihatosadat Gholam-Zadeh (Author), Sun-Young Yoon (Author), Jae-Hee Suh (Author), Hye-Seon Choi (Author)
• Format: Book
• Published: MDPI AG, 2021-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Loss of ovarian function is closely related to estrogen (E₂) deficiency, which is responsible for increased osteoclast (OC) differentiation and activity. We aimed to investigate the action mechanism of E₂ to decrease bone resorption in OCs to protect fro...