The systemic activin response to pancreatic cancer: implications for effective cancer cachexia therapy

• Main Authors: Xiaoling Zhong (Author), Marianne Pons (Author), Christophe Poirier (Author), Yanlin Jiang (Author), Jianguo Liu (Author), George E. Sandusky (Author), Safi Shahda (Author), Attila Nakeeb (Author), C. Max Schmidt (Author), Michael G. House (Author), Eugene P. Ceppa (Author), Nicholas J. Zyromski (Author), Yunlong Liu (Author), Guanglong Jiang (Author), Marion E. Couch (Author), Leonidas G. Koniaris (Author), Teresa A. Zimmers (Author)
• Format: Book
• Published: Wiley, 2019-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a particularly lethal malignancy partly due to frequent, severe cachexia. Serum activin correlates with cachexia and mortality, while exogenous activin causes cachexia in mice. Methods Isoform‐specific activin expression and activities w...