Site-specific 68Ga-labeled nanobody for PET imaging of CD70 expression in preclinical tumor models

• Main Authors: Jonatan Dewulf (Author), Tal Flieswasser (Author), Tim Delahaye (Author), Christel Vangestel (Author), Alan Miranda (Author), Hans de Haard (Author), Julie Jacobs (Author), Evelien Smits (Author), Tim Van den Wyngaert (Author), Filipe Elvas (Author)
• Format: Book
• Published: SpringerOpen, 2023-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background CD70-CD27 is a costimulatory ligand-receptor pair in the tumor necrosis factor receptor family. With only limited expression in normal tissues, CD70 is constitutively expressed in a variety of solid tumors and hematologic malignancies, facilitating immunosuppression through CD27...