Redistribution of Extracellular Superoxide Dismutase Causes Neonatal Pulmonary Vascular Remodeling and PH but Protects Against Experimental Bronchopulmonary Dysplasia

• Main Authors: Laurie G. Sherlock (Author), Ashley Trumpie (Author), Laura Hernandez-Lagunas (Author), Sarah McKenna (Author), Susan Fisher (Author), Russell Bowler (Author), Clyde J. Wright (Author), Cassidy Delaney (Author), Eva Nozik-Grayck (Author)
• Format: Book
• Published: MDPI AG, 2018-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: A naturally occurring single nucleotide polymorphism (SNP), (R213G), in extracellular superoxide dismutase (SOD3), decreases SOD3 matrix binding affinity. Humans and mature mice expressing the R213G SNP exhibit increased cardiovascular disease but decreased lung disease. The impact of th...