Piperine as Therapeutic Agent in Paracetamol-Induced Hepatotoxicity in Mice

• Main Authors: Aline Meireles Coelho (Author), Isabela Ferreira Queiroz (Author), Luiza Oliveira Perucci (Author), Melina Oliveira de Souza (Author), Wanderson Geraldo Lima (Author), André Talvani (Author), Daniela Caldeira Costa (Author)
• Format: Book
• Published: MDPI AG, 2022-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

High doses of paracetamol (APAP) can cause irreversible liver damage. Piperine (P) inhibits cytochrome P450, which is involved in the metabolism of various xenobiotics, including paracetamol. We evaluated the hepatoprotective effects of piperine with or without N-acetylcysteine (NAC) in APAP-induced...