Piperine as Therapeutic Agent in Paracetamol-Induced Hepatotoxicity in Mice

• Hoofdauteurs: Aline Meireles Coelho (Auteur), Isabela Ferreira Queiroz (Auteur), Luiza Oliveira Perucci (Auteur), Melina Oliveira de Souza (Auteur), Wanderson Geraldo Lima (Auteur), André Talvani (Auteur), Daniela Caldeira Costa (Auteur)
• Formaat: Boek
• Gepubliceerd in: MDPI AG, 2022-08-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

High doses of paracetamol (APAP) can cause irreversible liver damage. Piperine (P) inhibits cytochrome P450, which is involved in the metabolism of various xenobiotics, including paracetamol. We evaluated the hepatoprotective effects of piperine with or without N-acetylcysteine (NAC) in APAP-induced...