Increased Tumoral Microenvironmental pH Improves Cytotoxic Effect of Pharmacologic Ascorbic Acid in Castration-Resistant Prostate Cancer Cells

• Main Authors: Zhoulei Li (Author), Peng He (Author), Ganhua Luo (Author), Xinchong Shi (Author), Gang Yuan (Author), Bing Zhang (Author), Christof Seidl (Author), Andreas Gewies (Author), Yue Wang (Author), Yuan Zou (Author), Yali Long (Author), Dianchao Yue (Author), Xiangsong Zhang (Author)
• Format: Book
• Published: Frontiers Media S.A., 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundThe anticancer potential of pharmacologic ascorbic acid (AA) has been detected in a number of cancer cells. However, in vivo study suggested a strongly reduced cytotoxic activity of AA. It was known that pH could be a critical influencing factor for multiple anticancer treatments. In this...