Losartan Inhibits SARS-CoV-2 Replication in Vitro

• Main Authors: Reza Nejat (Author), Ahmad Shahir Sadr (Author), Branden Freitas (Author), Jackelyn Crabttree (Author), Scott D. Pegan (Author), Ralph A. Tripp (Author), David Najafi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on SARS-CoV-2 replication and inhibition of the papain-like protease of the virus. Methods: The dose-dependent inhibitory effec...