Depletion of Labile Iron Induces Replication Stress and Enhances Responses to Chemoradiation in Non-Small-Cell Lung Cancer

• Main Authors: Khaliunaa Bayanbold (Author), Mekhla Singhania (Author), Melissa A. Fath (Author), Charles C. Searby (Author), Jeffrey M. Stolwijk (Author), John B. Henrich (Author), Casey F. Pulliam (Author), Joshua D. Schoenfeld (Author), Kranti A. Mapuskar (Author), Sei Sho (Author), Joseph M. Caster (Author), Bryan G. Allen (Author), Garry R. Buettner (Author), Maria Spies (Author), Prabhat C. Goswami (Author), Michael S. Petronek (Author), Douglas R. Spitz (Author)
• Format: Book
• Published: MDPI AG, 2023-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The intracellular redox-active labile iron pool (LIP) is weakly chelated and available for integration into the iron metalloproteins that are involved in diverse cellular processes, including cancer cell-specific metabolic oxidative stress. Abnormal iron metabolism and elevated LIP levels are linked...